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Article

A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication.

The Journal of biological chemistry - 5 Sept 2014

Hatakeyama Dai, Shoji Masaki, Yamayoshi Seiya, Hirota Takenori, Nagae Monami, Yanagisawa Shin, Nakano Masahiro, Ohmi Naho, Noda Takeshi, Kawaoka Yoshihiro, Kuzuhara Takashi

Abstract excerpt

The PA, PB1, and PB2 subunits, components of the RNA-dependent RNA polymerase of influenza A virus, are essential for viral transcription and replication. The PB2 subunit binds to the host RNA cap (7-methylguanosine triphosphate (m(7)GTP)) and supports the endonuclease activity of PA to "snatch" the cap from host pre-mRNAs. However, the structure of PB2 is not fully understood, and the functional sites remain...

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Identifiers

PMID: 25063805
DOI: 10.1074/jbc.M114.559708
PMCID: PMC4155666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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