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Article

Role of the PB2 627 Domain in Influenza A Virus Polymerase Function

26 Jan 2017

Abstract excerpt

ABSTRACT The RNA genome of influenza A viruses is transcribed and replicated by the viral RNA-dependent RNA polymerase, composed of the subunits PA, PB1, and PB2. High-resolution structural data revealed that the polymerase assembles into a central polymerase core and several auxiliary highly flexible, protruding domains. The auxiliary PB2 cap-binding and the PA endonuclease domains are both involved in cap...

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PMID: 28122973
DOI: 10.1128/jvi.02467-16

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