Article

N-terminal acetylation controls multiple functional aspects of the influenza A virus ribonuclease PA-X

2023-12-02

Abstract excerpt

To counteract host antiviral responses, influenza A virus triggers a global reduction of cellular gene expression, a process termed “host shutoff.” A key effector of influenza A virus host shutoff is the viral endoribonuclease PA-X, which degrades host mRNAs. While many of the molecular determinants of PA-X activity remain unknown, a previous study found that N-terminal acetylation of PA-X is required for its host...

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Literature Corpus work: 4438a5fa-743f-526c-9a93-447d23b92f5d
DOI: 10.1101/2023.12.01.569683

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