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Article

Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase.

The EMBO journal - 17 Jun 2009

Sugiyama Kanako, Obayashi Eiji, Kawaguchi Atsushi, Suzuki Yukari, Tame Jeremy R H, Nagata Kyosuke, Park Sam-Yong

Abstract excerpt

Influenza virus RNA-dependent RNA polymerase is a multi-functional heterotrimer, which uses a 'cap-snatching' mechanism to produce viral mRNA. Host cell mRNA is cleaved to yield a cap-bearing oligonucleotide, which can be extended using viral genomic RNA as a template. The cap-binding and endonuclease activities are only activated once viral genomic RNA is bound. This requires signalling from the RNA-binding PB1...

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Identifiers

PMID: 19461581
DOI: 10.1038/emboj.2009.138
PMCID: PMC2699363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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