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Article

Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding.

The Journal of biological chemistry - 30 May 2003

Fechter Pierre, Mingay Louise, Sharps Jane, Chambers Anna, Fodor Ervin, Brownlee George G

Abstract excerpt

mRNAs are capped at their 5'-end by a unique cap structure containing N7-methyl guanine. Recognition of the cap structure is of paramount importance in some of the most central processes of gene expression as well as in some viral processes, such as priming of influenza virus transcription. The recent resolution of the structure of three evolutionary unrelated cap binding proteins, the vaccinia viral protein...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12646557
DOI: 10.1074/jbc.M300130200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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