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Article

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers.

The Journal of antimicrobial chemotherapy - 1 Nov 2014

Riveira-Muñoz Eva, Ruiz Alba, Pauls Eduardo, Permanyer Marc, Badia Roger, Mothe Beatriz, Crespo Manel, Clotet Bonaventura, Brander Christian, Ballana Ester, Esté José A

Abstract excerpt

OBJECTIVES: SAMHD1 and the CDKN1A (p21) cyclin-dependent kinase inhibitor have been postulated to mediate HIV-1 restriction in CD4+ cells. We have shown that p21 affects HIV replication through its effect on SAMHD1. Thus, we aimed at evaluating the expression of SAMHD1 and p21 in different HIV+ phenotypic groups. PATIENTS AND METHODS: We evaluated SAMHD1 and CDKN1A mRNA expression in CD4+ T cells from HIV+...

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Share to Gene Expression Regulation, Enzymologic
Share to SAMHD1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to SAM Domain and HD Domain-Containing Protein 1

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Source

Identifiers

PMID: 25063780
DOI: 10.1093/jac/dku276

Genes

SAMHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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