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Article

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

14 Mar 2011

Abstract excerpt

Elite controllers represent a unique group of HIV-1-infected persons with undetectable HIV-1 replication in the absence of antiretroviral therapy. However, the mechanisms contributing to effective viral immune defense in these patients remain unclear. Here, we show that compared with HIV-1 progressors and HIV-1-negative persons, CD4+ T cells from elite controllers are less susceptible to HIV-1 infection. This...

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PMID: 21403397
DOI: 10.1172/jci44539

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