Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms of the SAMHD1 gene are not associated with the infection and natural control of HIV type 1 in Europeans and African-Americans.

AIDS research and human retroviruses - 1 Dec 2012

Coon Sirena, Wang Danxin, Wu Li

Abstract excerpt

The HIV-1 restriction factor SAM domain and HD domain-containing protein 1 (SAMHD1) blocks HIV-1 infection in human myeloid cells. Mutations in the SAMHD1 gene are associated with rare genetic diseases including Aicardi-Goutieres syndrome. However, it is unknown whether polymorphisms of SAMHD1 are associated with infection and natural control of HIV-1 in humans. Our objective was to determine whether the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to HIV Infections

Share to Monomeric GTP-Binding Proteins

Share to Polymorphism, Single Nucleotide

Share to SAM Domain and HD Domain-Containing Protein 1

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 22530776
DOI: 10.1089/AID.2012.0039
PMCID: PMC3505062

Genes

SAMHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of the SAMHD1 gene are not associated with the infection and natural control of HIV type 1 in Europeans and African-Americans.PMID 22530776Read ↗

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.Semantic proximity Read ↗

SAMHD1’s protein expression profile in humansSemantic proximity Read ↗

Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.Semantic proximity Read ↗

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.Semantic proximity Read ↗

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30aSemantic proximity Read ↗

A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.Semantic proximity Read ↗

SAMHD1 Impairs HIV-1 Gene Expression and Reactivation of Viral Latency in CD4 <sup>+</sup> T-cellsSemantic proximity Read ↗

SAMHD1: a new contributor to HIV-1 restriction in resting CD4+T-cellsSemantic proximity Read ↗

SAMHD1 restricts HIV-1 infection in resting CD4+ T cellsSemantic proximity Read ↗

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathwaysSemantic proximity Read ↗

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damageSemantic proximity Read ↗

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.