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Article

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.

PLoS pathogens - 1 Dec 2011

Berger André, Sommer Andreas F R, Zwarg Jenny, Hamdorf Matthias, Welzel Karin, Esly Nicole, Panitz Sylvia, Reuter Andreas, Ramos Irene, Jatiani Asavari, Mulder Lubbertus C F, Fernandez-Sesma Ana, Rutsch Frank, Simon Viviana, König Renate, Flory Egbert

Abstract excerpt

Myeloid blood cells are largely resistant to infection with human immunodeficiency virus type 1 (HIV-1). Recently, it was reported that Vpx from HIV-2/SIVsm facilitates infection of these cells by counteracting the host restriction factor SAMHD1. Here, we independently confirmed that Vpx interacts with SAMHD1 and targets it for ubiquitin-mediated degradation. We found that Vpx-mediated SAMHD1 degradation rendered...

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Source

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Identifiers

PMID: 22174685
DOI: 10.1371/journal.ppat.1002425
PMCID: PMC3234228

Genes

SAMHD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.PMID 22174685Read ↗

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