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Article

Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.

Virology - 1 Jul 2014

White Tommy E, Brandariz-Nuñez Alberto, Valle-Casuso Jose Carlos, Knowlton Caitlin, Kim Baek, Sawyer Sara L, Diaz-Griffero Felipe

Abstract excerpt

SAMHD1 is a human restriction factor that prevents efficient infection of macrophages, dendritic cells and resting CD4+ T cells by HIV-1. Here we explored the antiviral activity and biochemical properties of human SAMHD1 polymorphisms. Our studies focused on human SAMHD1 polymorphisms that were previously identified as evolving under positive selection for rapid amino acid replacement during primate speciation....

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Share to Polymorphism, Single Nucleotide
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to SAM Domain and HD Domain-Containing Protein 1

Source

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Identifiers

PMID: 25010268
DOI: 10.1016/j.virol.2014.04.023
PMCID: PMC4101048

Genes

SAMHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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