Article
Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy.
PloS one - 1 Jan 2013
Kostic Corinne, Lillico Simon Geoffrey, Crippa Sylvain Vincent, Grandchamp Nicolas, Pilet Héloïse, Philippe Stéphanie, Lu Zen, King Tim James, Mallet Jacques, Sarkis Chamsy, Arsenijevic Yvan, Whitelaw Christopher Bruce Alexander
Abstract excerpt
Large animal models are an important resource for the understanding of human disease and for evaluating the applicability of new therapies to human patients. For many diseases, such as cone dystrophy, research effort is hampered by the lack of such models. Lentiviral transgenesis is a methodology broadly applicable to animals from many different species. When conjugated to the expression of a dominant mutant...
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