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Article

Cognitive deficits in transgenic and knock-in HTT mice parallel those in Huntington's disease.

Journal of Huntington's disease - 1 Jan 2014

Farrar Andrew M, Murphy Carol A, Paterson Neil E, Oakeshott Stephen, He Dansha, Alosio William, McConnell Kristi, Menalled Liliana B, Ramboz Sylvie, Park Larry C, Howland David, Brunner Dani

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is characterized not only by severe motor deficits but also by early cognitive dysfunction that significantly increases the burden of the disease for patients and caregivers. Considerable efforts have concentrated, therefore, on the assessment of cognitive deficits in some HD mouse models. However, many of these models that exhibit cognitive deficits also have contemporaneous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25062858
DOI: 10.3233/JHD-130061

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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