Article
Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease.
Brain research bulletin - 28 Apr 2006
Brooks S P, Betteridge H, Trueman R C, Jones L, Dunnett S B
Abstract excerpt
People with early-stage Huntington's disease have been found to have a specific deficit in performing an extra-dimensional shift. To date no evidence of this deficit has been identified in transgenic or knock-in rodent models of the disease. The aim of the present paper then, was to test whether homozygous knock-in mice derived from the Hdh(CAG(150)) mouse line were impaired in any of five 2-choice discrimination...
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