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Article

Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight.

BMC biology - 23 May 2024

Koch Ellen T, Cheng Judy, Ramandi Daniel, Sepers Marja D, Hsu Alex, Fong Tony, Murphy Timothy H, Yttri Eric, Raymond Lynn A

Abstract excerpt

BACKGROUND: Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of the human disease. However, behavioural phenotypes are often subtle and progress slowly in this model. Here, we have implemented machine-learning algorithms to investigate behaviour in the Q175...

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Identifiers

PMID: 38783261
DOI: 10.1186/s12915-024-01919-9
PMCID: PMC11119712

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