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p16INK4a reporter mice reveal age-promoting effects of environmental toxicants

15 Dec 2013

Abstract excerpt

While murine-based systems to identify cancer-promoting agents (carcinogens) are established, models to identify compounds that promote aging (gerontogens) have not been described. For this purpose, we exploited the transcription of p16INK4a, which rises dynamically with aging and correlates with age-associated disease. Activation of p16INK4a was visualized in vivo using a murine strain that harbors a knockin of...

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PMID: 24334456
DOI: 10.1172/jci70960

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