Article
Genetic variants in AKT1 gene were associated with risk and survival of OSCC in Chinese Han Population.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jan 2015
Wang Yun, Lin Lin, Xu Hao, Li Taiwen, Zhou Yu, Dan Hongxia, Jiang Lu, Liao Ga, Zhou Min, Li Longjiang, Zeng Xin, Li Jing, Chen Qianming
Abstract excerpt
BACKGROUND: AKT1 is an important downstream effector of PTEN/PI3K/AKT signal transduction pathway. Aberrant expression and genetic variant of AKT1 gene are suggested to be involved in several types of human cancers, including OSCC. The aim of this study was to investigate the possible association between AKT1 gene polymorphisms and OSCC in Chinese Han Population. METHODS: A total of 182 OSCC patients and 207...
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