KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasis

Abstract excerpt

The major cause of treatment failure and mortality among medulloblastoma patients is metastasis intracranially or along the spinal cord. The molecular mechanisms driving tumor metastasis in Sonic hedgehog-driven medulloblastoma (SHH-MB) patients, however, remain largely unknown. In this study we define a tumor suppressive role of KMT2D ( MLL2 ), a gene frequently mutated in the most metastatic β-subtype....

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