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Molecular Determinants of Medulloblastoma Metastasis and Leptomeningeal Dissemination

19 Feb 2021

Abstract excerpt

Abstract Medulloblastoma is the most common malignant brain cancer in pediatrics consisting of four molecular subgroups, namely wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. One of the biggest challenges in the clinical management of this disease is the leptomeningeal dissemination (LMD) of tumor cells with high morbidity and mortality. Many molecular regulators to date have been identified to...

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PMID: 33608450
DOI: 10.1158/1541-7786.mcr-20-1026

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