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Article

β-Defensin genomic copy number does not influence the age of onset in Huntington's Disease.

Journal of Huntington's disease - 1 Jan 2013

Vittori Angelica, Orth Michael, Roos Raymund A C, Outeiro Tiago F, Giorgini Flaviano, Hollox Edward J

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the abnormal expansion of a CAG triplet repeat tract in the huntingtin gene. While the length of this CAG expansion is the major determinant of the age of onset (AO), other genetic factors have also been shown to play a modulatory role. Recent evidence suggests that neuroinflammations is a pivotal factor in the...

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PMID: 25057107
DOI: 10.3233/JHD-130002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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