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Article

PGC-1alphaas modifier of onset age in Huntington disease

6 Feb 2009

Abstract excerpt

Although there is a strong correlation between CAG repeat length and age at onset (AO) of motor symptoms, individual Huntington disease (HD) patients may differ dramatically in onset age and disease manifestations despite similar CAG repeat lengths. This has led to a search for genetic factors that influence AO. In order to identify such a genetic modifier, we analysed polymorphisms in the PGC-1alpha gene. Recent...

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PMID: 19200361
DOI: 10.1186/1750-1326-4-10

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