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Article

Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2.

EMBO reports - 1 Sept 2014

Katsumura Koichi R, Yang Chenxi, Boyer Meghan E, Li Lingjun, Bresnick Emery H

Abstract excerpt

Disease mutations provide unique opportunities to decipher protein and cell function. Mutations in the master regulator of hematopoiesis GATA-2 underlie an immunodeficiency associated with myelodysplastic syndrome and leukemia. We discovered that a GATA-2 disease mutant (T354M) defective in chromatin binding was hyperphosphorylated by p38 mitogen-activated protein kinase. p38 also induced multisite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25056917
DOI: 10.15252/embr.201438808
PMCID: PMC4198037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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