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Article

GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells

1 Aug 2016

Abstract excerpt

The master regulatory transcription factor GATA-2 triggers hematopoietic stem and progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and GATA2 overexpression portends a poor prognosis for AML. However, the constituents of the GATA-2-dependent genetic network mediating pathogenesis are unknown. We described a p38-dependent...

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PMID: 27545880
DOI: 10.1016/j.celrep.2016.07.058

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