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Article

Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.

Molecular and cellular biology - 1 Aug 2009

Yang Zhenyun, Kondo Takako, Voorhorst Cara S, Nabinger Sarah C, Ndong Leila, Yin Fuqin, Chan Edward M, Yu Menggang, Würstlin Oliver, Kratz Christian P, Niemeyer Charlotte M, Flotho Christian, Hashino Eri, Chan Rebecca J

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is characterized by myelomonocytic cell overproduction and commonly bears activating mutations in PTPN11. Murine hematopoietic progenitors expressing activating Shp2 undergo myelomonocytic differentiation, despite being subjected to conditions that normally support only mast cells. Evaluation of hematopoietic-specific transcription factor expression indicates reduced GATA2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to JNK Mitogen-Activated Protein Kinases

Share to Leukemia, Myelomonocytic, Juvenile

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Receptor, Macrophage Colony-Stimulating Factor

Source

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Identifiers

PMID: 19528235
DOI: 10.1128/MCB.01330-08
PMCID: PMC2725726

Genes

GATA2
PTPN11
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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