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Article

The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA Repair.

Scientific reports - 24 Jul 2014

Chen Bert Yu-Hung, Huang Cheng-Hsiang, Lin Ying-Hsi, Huang Ching-Chun, Deng Chu-Xia, Hsu Lih-Ching

Abstract excerpt

BRCA1 is a phosphoprotein involved in many biological processes, including transcription, ubiquitination, checkpoint control, homologous recombination, and DNA repair. We have demonstrated that protein phosphatase 1α (PP1α) interacts with BRCA1 via a PP1-binding motif (898)KVTF(901), and can dephosphorylate multiple serine residues phosphorylated by checkpoint kinases. A K898E germline missense variant in the...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25056273
DOI: 10.1038/srep05812
PMCID: PMC4108927

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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