Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer.

doi:10.1007/s11033-012-2424-z

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Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer.

Molecular biology reports - 1 May 2013

Forma Ewa, Brzeziańska Ewa, Krześlak Anna, Chwatko Grażyna, Jóźwiak Paweł, Szymczyk Agnieszka, Smolarz Beata, Romanowicz-Makowska Hanna, Różański Waldemar, Bryś Magdalena

Abstract excerpt

Topoisomerase IIβ binding protein 1 (TopBP1) is involved in cell survival, DNA replication, DNA damage repair and cell cycle checkpoint control. The biological function of TopBP1 and its close relation with BRCA1 prompted us to investigate whether alterations in the TopBP1 gene can influence the risk of breast cancer. The aim of this study was to examine the association between five polymorphisms (rs185903567,...

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PMID: 23277395
DOI: 10.1007/s11033-012-2424-z
PMCID: PMC3611025

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BRCA1

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