Article
Role of nuclear Lamin A/C in cardiomyocyte functions.
Biology of the cell - 1 Oct 2014
Carmosino Monica, Torretta Silvia, Procino Giuseppe, Gerbino Andrea, Forleo Cinzia, Favale Stefano, Svelto Maria
Abstract excerpt
Lamin A/C is a structural protein of the nuclear envelope (NE) and cardiac involvement in Lamin A/C mutations was one of the first phenotypes to be reported in humans, suggesting a crucial role of this protein in the cardiomyocytes function. Mutations in LMNA gene cause a class of pathologies generically named 'Lamanopathies' mainly involving heart and skeletal muscles. Moreover, the well-known disease called...
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