Article
Lamin and the heart.
Heart (British Cardiac Society) - 1 Mar 2018
Captur Gabriella, Arbustini Eloisa, Bonne Gisèle, Syrris Petros, Mills Kevin, Wahbi Karim, Mohiddin Saidi A, McKenna William J, Pettit Stephen, Ho Carolyn Y, Muchir Antoine, Gissen Paul, Elliott Perry M, Moon James C
Abstract excerpt
Lamins A and C are intermediate filament nuclear envelope proteins encoded by the LMNA gene. Mutations in LMNA cause autosomal dominant severe heart disease, accounting for 10% of dilated cardiomyopathy (DCM). Characterised by progressive conduction system disease, arrhythmia and systolic impairment, lamin A/C heart disease is more malignant than other common DCMs due to high event rates even when the left...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.