Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP).

doi:10.1111/j.1651-2227.2008.01131.x

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Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP).

Acta paediatrica (Oslo, Norway : 1992) - 1 Mar 2009

Cummings Kevin J, Klotz Cherise, Liu Wei-Qiao, Weese-Mayer Debra E, Marazita Mary L, Cooper Margaret E, Berry-Kravis Elizabeth M, Tobias Rose, Goldie Cameron, Bech-Hansen N Torben, Wilson Richard Ja

Abstract excerpt

AIMS: Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) are prone to sudden death in the second post-natal week, having respiratory and metabolic disturbances reminiscent of the human Sudden Infant Death Syndrome (SIDS). Here we test the hypothesis that the human PACAP gene is a site of genetic variance associated with SIDS in a cohort of 92 victims and 92 matched controls. METHODS: Using...

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Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP).

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