<i>Jagged1</i> Ablation Results in Cerebellar Granule Cell Migration Defects and Depletion of Bergmann Glia

Abstract excerpt

Jagged1 is a ligand for members of the Notch family of receptors. Mutations in the human JAG1 gene are the major cause of Alagille syndrome, an autosomal dominant disorder affecting the liver, heart, eye, skeleton, kidneys, and craniofacial structures. Although expressed throughout mammalian embryonic development and in the adult, the function of Jagged1 in the central nervous system is not clear. Jagged1 is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic and Kidney Cyst Diseases
• Share to Genetics and Neurodevelopmental Disorders
• Share to Pediatric Hepatobiliary Diseases and Treatments