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Article

Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice.

PloS one - 1 Jan 2016

Li Zhenzu, Zhang Tingting, Lin Zhuchun, Hou Congzhe, Zhang Jian, Men Yuqin, Li Huashun, Gao Jiangang

Abstract excerpt

Lethal giant larvae 1 (Lgl1) was initially identified as a tumor suppressor in Drosophila and functioned as a key regulator of epithelial polarity and asymmetric cell division. In this study, we generated Lgl1 conditional knockout mice mediated by Pax2-Cre, which is expressed in olfactory bulb (OB). Next, we examined the effects of Lgl1 loss in the OB. First, we determined the expression patterns of Lgl1 in the...

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Identifiers

PMID: 27603780
DOI: 10.1371/journal.pone.0162126
PMCID: PMC5014313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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