Article
HMGB1 gene polymorphism is associated with hypertension in Han Chinese population.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2015
Yao Yingshui, Guo Daoxia, Yang Song, Jin Yuelong, He Lianping, Chen Jinfeng, Zhao Xianghai, Chen Yanchun, Zhou Wei, Shen Chong
Abstract excerpt
BACKGROUND: High-mobility group box 1 protein (HMGB1) acts as a proinflammatory cytokine by activating pattern recognition receptors (PRRs), including Toll-like receptor 4 (TLR4) and the receptor of AGE (AGER) with oxidative injury. Animal study proved that HMGB1 contributed to the pathogenesis of experimental pulmonary hypertension (HT) via activation of TLR4. The aim of this study is to test whether HMGB1...
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