Article
Effects of HMGB1 Polymorphisms on the Susceptibility and Progression of Hepatocellular Carcinoma.
International journal of medical sciences - 1 Jan 2016
Wang Bin, Yeh Chao-Bin, Lein Ming-Yu, Su Chen-Ming, Yang Shun-Fa, Liu Yu-Fan, Tang Chih-Hsin
Abstract excerpt
Hepatocellular carcinoma (HCC) is a malignancy of liver and a leading cause of cancer mortality worldwide. Its management is compounded by biological and clinical heterogeneity. These interindividual genetic variations can modulate the effects of HCC treatment. High-mobility group box protein 1 (HMGB1) is a well investigated, ubiquitous nuclear protein found in eukaryotic cells that plays a multiple biological...
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