Article
Elevated receptor for activated C kinase 1 expression is involved in intracellular Ca2+ influx and potentially associated with compromised regulatory T cell function in patients with asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Sept 2014
Negoro T, Shimizu S, Narushima M, Banham A H, Wakabayashi H, Takayanagi R, Hagiwara T, Roncador G, Osabe T, Yanai T, Kin M, Ikeda K, Endo A, Akiyama H, Nakano Y
Abstract excerpt
BACKGROUND: Regulatory T cells (T(regs)) are activated during anergy in response to T cell receptor (TCR) activation and functional immune suppression. Anergy of paediatric T(regs) is partially dependent on intracellular calcium mobility; following TCR activation, T(regs) do not exhibit increased intracellular Ca(2+) concentration ([Ca(2+) ](i)). OBJECTIVE: We determined whether [Ca(2+) ](i) in adult T(regs)...
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