Article
Prevalence of single nucleotide polymorphisms in the Plasmodium falciparum multidrug resistance gene (Pfmdr-1) in Korogwe District in Tanzania before and after introduction of artemisinin-based combination therapy.
The American journal of tropical medicine and hygiene - 1 Dec 2011
Thomsen Thomas T, Ishengoma Deus S, Mmbando Bruno P, Lusingu John P, Vestergaard Lasse S, Theander Thor G, Lemnge Martha M, Bygbjerg Ib C, Alifrangis Michael
Abstract excerpt
Tanzania implemented artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in November of 2006 because of resistance to sulfadoxine-pyrimethamine. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance, which initially may be detected at the molecular level as temporal changes in the frequency of single nucleotide...
Topics
- ATP-Binding Cassette Transporters
- Antimalarials
- Artemisinins
- Codon
- Cross-Sectional Studies
- Drug Resistance, Multiple
- Drug Therapy, Combination
- Ethanolamines
- Fluorenes