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Article

Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria.

Antimicrobial agents and chemotherapy - 1 Mar 2007

Humphreys G S, Merinopoulos I, Ahmed J, Whitty C J M, Mutabingwa T K, Sutherland C J, Hallett R L

Abstract excerpt

The artemisinin-based combination therapies artemether-lumefantrine (AL) and amodiaquine (AQ) plus artesunate have been adopted for treatment of Plasmodium falciparum malaria in many African countries. Molecular markers of parasite resistance suitable for surveillance have not been established for any of the component drugs in either of these combinations. We assessed P. falciparum mdr1 (Pfmdr1) alleles present...

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Identifiers

PMID: 17194834
DOI: 10.1128/AAC.00875-06
PMCID: PMC1803116

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Source receipt: pubmed, retrieved 7 Sept 2026.

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