Fixed-Dose Artesunate-Amodiaquine Combination vs Chloroquine for Treatment of Uncomplicated Blood Stage P. vivax Infection in the Brazilian Amazon: An Open-Label Randomized, Controlled Trial.

doi:10.1093/cid/ciw706

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Article

Fixed-Dose Artesunate-Amodiaquine Combination vs Chloroquine for Treatment of Uncomplicated Blood Stage P. vivax Infection in the Brazilian Amazon: An Open-Label Randomized, Controlled Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jan 2017

Siqueira Andre M, Alencar Aline C, Melo Gisely C, Magalhaes Belisa L, Machado Kim, Alencar Filho Aristóteles C, Kuehn Andrea, Marques Marly M, Manso Monica Costa, Felger Ingrid, Vieira José L F, Lameyre Valerie, Daniel-Ribeiro Claudio T, Lacerda Marcus V G

Abstract excerpt

BACKGROUND: Despite increasing evidence of the development of Plasmodium vivax chloroquine (CQ) resistance, there have been no trials comparing its efficacy with that of artemisinin-based combination therapies (ACTs) in Latin America. METHODS: This randomized controlled trial compared the antischizontocidal efficacy and safety of a 3-day supervised treatment of the fixed-dose combination artesunate-amodiaquine...

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PMID: 27988484
DOI: 10.1093/cid/ciw706
PMCID: PMC5215218

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