Article
Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significance.
Cellular and molecular life sciences : CMLS - 1 Jul 2006
Woodrow C J, Krishna S
Abstract excerpt
Molecular determinants of antimalarial drug resistance are useful and informative tools that complement phenotypic assays for drug resistance. They also guide the design of strategies to circumvent such resistance once it has reached levels of clinical significance. Established resistance to arylaminoalcohols such as mefloquine and lumefantrine in SE Asia is mediated primarily by gene amplification of the P....
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