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Mycobacterial Gene cuvA Is Required for Optimal Nutrient Utilization and Virulence

22 Jul 2014

Abstract excerpt

To persist and cause disease in the host, Mycobacterium tuberculosis must adapt to its environment during infection. Adaptations include changes in nutrient utilization and alterations in growth rate. M. tuberculosis Rv1422 is a conserved gene of unknown function that was found in a genetic screen to interact with the mce4 cholesterol uptake locus. The Rv1422 protein is phosphorylated by the M. tuberculosis...

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PMID: 25047842
DOI: 10.1128/iai.02207-14

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