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Article

The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.

Genes & development - 15 Jul 2005

Kang Choong-Min, Abbott Derek W, Park Sang Tae, Dascher Christopher C, Cantley Lewis C, Husson Robert N

Abstract excerpt

The Mycobacterium tuberculosis genome contains 11 serine/threonine kinase genes including two, pknA and pknB, that are part of an operon encoding genes involved in cell shape control and cell wall synthesis. Here we demonstrate that pknA and pknB are predominantly expressed during exponential growth, and that overexpression of these kinases slows growth and alters cell morphology. We determined the preferred...

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Identifiers

PMID: 15985609
DOI: 10.1101/gad.1311105
PMCID: PMC1176007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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