Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Double deletion of PknI/DacB2 leads to attenuation of Mycobacterium tuberculosis for growth and virulence.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2020

Kandasamy Srinivasan, Palaniyandi Kannan, Gupta Umesh Datta, Narayanan Sujatha

Abstract excerpt

Serine/Threonine Protein Kinases (STPKs) phosphorylates target proteins thereby regulates various important cellular signal transduction pathways such as cell division and cell wall synthesis. It has been demonstrated that the STPKs regulate peptidoglycan biosynthesis by phosphorylating penicillin binding proteins (PBPs). We extensively characterized both PknI (STPK) and DacB2 (PBP) roles individually as well as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carboxypeptidases
Share to Guinea Pigs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Hydrogen-Ion Concentration

Share to Microbial Viability

Share to Mycobacterium tuberculosis

Share to THP-1 Cells

Share to Tuberculosis, Pulmonary

Source

Identifiers

PMID: 32741534
DOI: 10.1016/j.tube.2020.101957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Double deletion of PknI/DacB2 leads to attenuation of Mycobacterium tuberculosis for growth and virulence.PMID 32741534Read ↗

Phenotypic characterization of a novel double knockout PknI/DacB2 from Mycobacterium tuberculosis.Semantic proximity Read ↗

Serine threonine protein kinases of mycobacterial genus: phylogeny to functionSemantic proximity Read ↗

Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host.Semantic proximity Read ↗

Role of two‐component regulatory systems in intracellular survival of Mycobacterium tuberculosisSemantic proximity Read ↗

RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria.Semantic proximity Read ↗

Polyphosphate Deficiency in Mycobacterium tuberculosis Is Associated with Enhanced Drug Susceptibility and Impaired Growth in Guinea PigsSemantic proximity Read ↗

The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.Semantic proximity Read ↗

Mycobacterium tuberculosis supports protein tyrosine phosphorylation.Semantic proximity Read ↗

Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates <i>Mycobacterium tuberculosis</i> sensitivity to nitric oxide stressSemantic proximity Read ↗

A high-frequency single nucleotide polymorphism in the MtrB sensor kinase in clinical strains of Mycobacterium tuberculosis alters its biochemical and physiological properties.Semantic proximity Read ↗

Two-Component Regulatory Systems of MycobacteriaSemantic proximity Read ↗

Comprehensive Characterization of the Attenuated Double Auxotroph Mycobacterium tuberculosisΔleuDΔpanCD as an Alternative to H37RvSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.