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Article

Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host.

The Journal of biological chemistry - 10 Apr 2015

Nagarajan Sathya Narayanan, Upadhyay Sandeep, Chawla Yogesh, Khan Shazia, Naz Saba, Subramanian Jayashree, Gandotra Sheetal, Nandicoori Vinay Kumar

Abstract excerpt

The essential mycobacterial protein kinases PknA and PknB play crucial roles in modulating cell shape and division. However, the precise in vivo functional aspects of PknA have not been investigated. This study aims to dissect the role of PknA in mediating cell survival in vitro as well as in vivo. We observed aberrant cell shape and severe growth defects when PknA was depleted. Using the mouse infection model,...

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Identifiers

PMID: 25713147
DOI: 10.1074/jbc.M114.611822
PMCID: PMC4392265

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