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Article

Differential Bees Flux Balance Analysis with OptKnock for in silico microbial strains optimization.

PloS one - 1 Jan 2014

Choon Yee Wen, Mohamad Mohd Saberi, Deris Safaai, Illias Rosli Md, Chong Chuii Khim, Chai Lian En, Omatu Sigeru, Corchado Juan Manuel

Abstract excerpt

Microbial strains optimization for the overproduction of desired phenotype has been a popular topic in recent years. The strains can be optimized through several techniques in the field of genetic engineering. Gene knockout is a genetic engineering technique that can engineer the metabolism of microbial cells with the objective to obtain desirable phenotypes. However, the complexities of the metabolic networks...

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PMID: 25047076
DOI: 10.1371/journal.pone.0102744
PMCID: PMC4105462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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