Sensitivity analysis and adaptive mutation strategy differential evolution algorithm for optimizing enzymes' turnover numbers in metabolic models.

Abstract excerpt

Genome-scale metabolic network model (GSMM) based on enzyme constraints greatly improves general metabolic models. The turnover number ( k cat ${k}_{\mathrm{cat}}$ ) of enzymes is used as a parameter to limit the reaction when extending GSMM. Therefore, turnover number plays a crucial role in the prediction accuracy of cell metabolism. In this work, we proposed an enzyme-constrained GSMM parameter optimization...

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