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Article

Distinct macrophage populations and phenotypes associated with IL-4 mediated immunomodulation at the host implant interface.

Biomaterials science - 21 Oct 2020

Hachim Daniel, LoPresti Samuel T, Rege Rahul D, Umeda Yuta, Iftikhar Aimon, Nolfi Alexis L, Skillen Clint D, Brown Bryan N

Abstract excerpt

The host macrophage response to implants has shown to be affected by tissue location and physio-pathological conditions of the patient. Success in immunomodulatory strategies is thus predicated on the proper understanding of the macrophage populations participating on each one of these contexts. The present study uses an in vivo implantation model to analyze how immunomodulation via an IL-4 eluting implant...

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Identifiers

PMID: 32945303
DOI: 10.1039/d0bm00568a
PMCID: PMC7641101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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