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Article

Macrophage phenotypes modulate neoangiogenesis and fibroblast profiles in synovial-like organoid cultures.

Osteoarthritis and cartilage - 1 May 2025

Gao Qi, Zhang Xiurui, Makarcyzk Meagan J, Wong Laurel Elizabeth, Quig Madison Sidney Virgil, Shinohara Issei, Murayama Masatoshi, Chow Simon Kwoon-Ho, Bunnell Bruce A, Lin Hang, Goodman Stuart B

Abstract excerpt

OBJECTIVE: To investigate the interaction among the cells thought to be foundational to inflammation, fibrosis, and angiogenesis in the synovial membrane. METHOD: We encapsulated fibroblasts, polarized macrophages, and endothelial cells in a 3D culture system. We used this model to determine the cellular transcriptional profiles, cytokine secretion, and vascular formation associated with different macrophage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39978574
DOI: 10.1016/j.joca.2025.02.777
PMCID: PMC12182213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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