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Article

Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters.

Integrative biology : quantitative biosciences from nano to macro - 1 Sept 2014

MacKay Joanna L, Kumar Sanjay

Abstract excerpt

The GTPases RhoA and Rac1 are key regulators of cell spreading, adhesion, and migration, and they exert distinct effects on the actin cytoskeleton. While RhoA classically stimulates stress fiber assembly and contraction, Rac1 promotes branched actin polymerization and membrane protrusion. These competing influences are reinforced by antagonistic crosstalk between RhoA and Rac1, which has complicated efforts to...

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Identifiers

PMID: 25044255
DOI: 10.1039/c4ib00099d
PMCID: PMC4141552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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