Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5

Abstract excerpt

Rational design of proteins with novel binding specificities and increased affinity is one of the major goals of computational protein design. Epitope-scaffolds are a new class of antigens engineered by transplanting viral epitopes of predefined structure to protein scaffolds, or by building protein scaffolds around such epitopes. Epitope-scaffolds are of interest as vaccine components to attempt to elicit...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Glycosylation and Glycoproteins Research
• Share to HIV Research and Treatment
• Share to Monoclonal and Polyclonal Antibodies Research