Article
Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma.
Pigment cell & melanoma research - 1 Nov 2014
Mar Victoria J, Wong Stephen Q, Logan Aleksandra, Nguyen Trung, Cebon Jonathan, Kelly John W, Wolfe Rory, Dobrovic Alexander, McLean Catriona, McArthur Grant A
Abstract excerpt
Activating mutations in the GTPase RAC1 are a recurrent event in cutaneous melanoma. We investigated the clinical and pathological associations of RAC1(P29S) in a cohort of 814 primary cutaneous melanomas with known BRAF and NRAS mutation status. The RAC1(P29S) mutation had a prevalence of 3.3% and was associated with increased thickness (OR=1.6 P = 0.001), increased mitotic rate (OR=1.3 P = 0.03), ulceration...
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