Article
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nature genetics - 1 Sept 2012
Krauthammer Michael, Kong Yong, Ha Byung Hak, Evans Perry, Bacchiocchi Antonella, McCusker James P, Cheng Elaine, Davis Matthew J, Goh Gerald, Choi Murim, Ariyan Stephan, Narayan Deepak, Dutton-Regester Ken, Capatana Ana, Holman Edna C, Bosenberg Marcus, Sznol Mario, Kluger Harriet M, Brash Douglas E, Stern David F, Materin Miguel A, Lo Roger S, Mane Shrikant, Ma Shuangge, Kidd Kenneth K, Hayward Nicholas K, Lifton Richard P, Schlessinger Joseph, Boggon Titus J, Halaban Ruth
Abstract excerpt
We characterized the mutational landscape of melanoma, the form of skin cancer with the highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed melanomas had markedly more ultraviolet (UV)-like C>T somatic mutations compared to sun-shielded acral, mucosal and uveal melanoma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.