Article
Characterisation and outcome of RAC1 mutated melanoma.
European journal of cancer (Oxford, England : 1990) - 1 Apr 2023
Lodde Georg C, Jansen Philipp, Herbst Rudolf, Terheyden Patrick, Utikal Jochen, Pföhler Claudia, Ulrich Jens, Kreuter Alexander, Mohr Peter, Gutzmer Ralf, Meier Friedegund, Dippel Edgar, Weichenthal Michael, Sucker Antje, Placke Jan-Malte, Zaremba Anne, Albrecht Lea Jessica, Kowall Bernd, Galetzka Wolfgang, Becker Jürgen C, Tasdogan Alpaslan, Zimmer Lisa, Livingstone Elisabeth, Hadaschik Eva, Schadendorf Dirk, Ugurel Selma, Griewank Klaus
Abstract excerpt
BACKGROUND: Activating hot spot R29S mutations in RAC1, a small GTPase influencing several cellular processes including cell proliferation and cytoskeleton rearrangement, have been reported in up to 9% of sun-exposed melanomas. Clinical characteristics and treatment implications of RAC1 mutations in melanoma remain unclear. METHODS: We investigated the largest set (n = 64) of RAC1 mutated melanoma patients...
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